Why Shiver?

Girlfriend To Stay Underneath Blanket For Next 5 Months
Girlfriend To Stay Underneath Blanket For Next 5 Months

Notes from Truelearn and UpToDate on Shivering in OB

Shivering during labor

  • 10-20% of laboring patients without epidural, 30-55% with epidural
  • multifactorial
  • hormonal changes: less progesterone than normal cycle results in less NE -> less augmentation of core temps
  • immunological reaction to fetomaternal transfusion
  • use of Misoprostol
  • possibly non-thermogenic: bursting tremor similar to clonus
  • Epidural shivering from central hypothermia and peripheral vasoconstriction
  • First hour with an epidural: core heat -> periphery 2/2 neuraxial blunt autonomic thermoregulatory below level of blockade, vasodilation causes redistribution of heat

Prevention and Treatment

  • Warming prior to epidural/spinal placement can decrease shivering
  • Warming after shivering
  • Dopaminergic/seretonergic pathway drugs can reduce shivering (25mg IV Meperidine (demerol), clonidine, tramadol, ketamine, dexmedatomidine)

Pediatric Anesthesia Reference Guide

In my dream the Lord did come to me, and He was a shape. It was He Who Walks Behind the Rows.
In my dream the Lord did come to me, and He was a shape. It was He Who Walks Behind the Rows.

UCSF once had an excellent PDF of the essentials to pediatric anesthesia (doses, tube sizes, etc), but that has since been lost to the internet. In searching for a replacement, I came across the Open Anesthesia page on peds, and it has just about everything!

Check it out here: https://www.openanesthesia.org/pediatric_anesthesia_anesthesia_text/

Note that when waking a patient up on precedex (deep) use 0.3mcg/kg as your dose and be sure to extubate deep (1 mac) .

Another reference site is found at Stony Brook, which is a bit more specific to drug doses, see here: https://medicine.stonybrookmedicine.edu/anesthesiology/teaching/peds-drug-dosages

In the interest of internet information preservation, the full text of the website is below:

Pediatric Anesthesia (Anesthesia Text)

Introduction

Anesthesia-related morbidity and mortality is higher in infants than adults, as well as in younger compared to older children. In particular, airway complications are more likely in very young infants. Critical events are highest in infants < 2 kg [Tay et. al. Paediatr Anaesth 11: 711, 2001]

Preoperative Checklist

Warm the room, peds Bear hugger, overhead warming lights, age appropriate headrest and monitors. IV setup in room. See patient early to determine need for premedication needs. For latex precautions, use latex free gloves, black bag on circuit, latex-free IV setup (clear masks are OK, as are ETT, LMA, and pink tape)

  • Warm the room
  • Peds Bair hugger
  • Overhead
  • Warming lights
  • Age appropriate headrest and monitors
  • IV setup in room
  • See patient early to determine need for premedication needs
  • For latex precautions, use latex free gloves, black bag on circuit, latex-free IV setup (clear masks are OK, as are ETT, LMA, and tape)

Pediatric Airway

The tongue is relatively larger, thus making a disproportionate contribution to airway obstruction and moving the glottis anteriorly (especially in children with craniofacial abnormalities, NMJ or CNS disease, tumors, hemangiomas, or URIs). Flexion of an infant’s head may collapse the airway

Pediatric patients often have less pulmonary reserve than adults, and require significantly more oxygen intake, thus they are prone to apnea during direct laryngoscopy

The larynx in infants is located at C3-4 (as opposed to C4-5 in adults). The infant epiglottis is large but short and narrow, possibly making a direct view of the larynx easier than in an adult. Note that the posterior commissure is relatively cephalad, predisposing the anterior sublaryngeal airway to trauma from the ETT. The narrowest portion of the infant airway is the cricoid cartilage, which can lead to resistance after passing an ETT through the cords

Cuffed vs. Uncuffed ETT

In 2009 a multicenter study comparing Microcuff tubes to uncuffed tubes in 2246 children showed that rates of tube exchange were 2.1% with cuffed compared with 30.8% for conventional tubes (p < 0.0001), and that rates of post-extubation stridor were equal in both groups. Furthermore, the cuff significantly improved the accuracy of the ET monitor. Anesthesia providers could ventilate with an average cuff pressure of 10 cm H20 [Weiss M et al. Br J Anaesth 103: 867, 2009].

Pediatric Endotracheal Tube Size

Age Internal Diameter (mm) Depth (cm)
Preterm 2.5 6 – 8
Term 3.0 9 – 10
6 months 3-3.5 10
1 – 2 years 4.0 10 – 11
3 – 4 years 4.5 12 – 13
5 – 6 years 5.0 14 – 15
10 years 6.0 16 – 17

Pediatric Endotracheal Tube Depth

For preemies and neonates (cm) = weight (in kg) + 6 For 1 year or older (cm) = age + 10 cm

Pediatric Airway Equipment

Age Miller Blade
< 32 weeks 00
Term 0 (< 3 kg)
3-18 mo. 1 (3-10 kg)
> 18 mo 2 (> 12 kg)

Pediatric LMA Size

LMA sizes ~ weight (kg) / 20 + 1 (round to nearest 0.5)

Organ Systems

Cardiovascular

Fetal circulation displays 1) increased PVR 2) decreased Qpulm 3) decreased SVR 4) RtoL shunting through foramen ovale. Hypoxemia or acidosis in the newborn can cause a return to fetal circulation

Neonatal hearts are relatively non-compliant and thus stroke volume is relatively fixed – they rely entirely on heart rate to manage cardiac output

Murmurs, abnormal heart sounds, dysrhythmias, and cardiomegaly are all important when noted in a newborn. EKG, CXR, and echo are therefore often required

Normal Physiologic Variables

Age BP (mmHg) HR (/min) RR (/min) Hct (%)
1 kg 45/30 120 – 180 40 – 50
2 kg 55/35 110 – 180 40 – 50
3 kg 65/40 100 – 180 40 – 60 45 – 65
Neonate 75/45 100 – 180 35 – 55 45 – 65
6 mo. 85/50 80 – 180 30 – 50 30 – 40 (nadir)
1 year 95/55 80 – 130 20 – 30 34 – 42
10 year 110/60 60 – 100 20 35 – 43
Adult 110/60 60 – 100 15 40 – 50

Hypovolemia

Hypotension is a late finding in pediatric patients (children may maintain a normal blood pressure until 35% of blood volume is lost). Tachycardia is sensitive but not specific indicator. Prolonged capillary refill (> 2 seconds), especially when combined with tachycardia, is more specific, although it may be difficult to measure. Cold skin and decreased urine output may be present. Weak pulses, mottling, cyanosis, and impaired consciousness may all precede hypotension. In fact, hypotension is an ominous sign in pediatric patients

Hypovolemia in Pediatrics: Signs

  • Tachycardia: sensitive but not specific. Resolution may help guide therapy
  • Delayed Capillary Refill: specific if > 2 seconds
  • Others: weak pulses, mottling, cyanosis, and impaired consciousness (may all precede hypotension), cold skin, decreased urine output
  • Hypotension: late finding. OMINOUS

 

Pulmonary

The lung is not fully formed at birth, and increases from 20 MM alveoli to 300 MM by 18 months of age. Newborn ribcages are particularly compliant and have a circular (non-ellipsoid) configuration as well as a horizontal (non-oblique) insertion of the diaphragm, all of which lead to inefficient diaphragmatic contraction. Worse, full-term infant diaphragms only have 25% type I (slow twitch) fibers, as opposed to 55% in adults

FEN/Renal System

Newborns

Newborns have decreased GFR, decreased ability to excrete solid material, and decreased ability to concentrate urine (ie conserve water). Adult values of GFR are reached between 12 and 24 months of life

Age (weeks) Urine Output (ml/h)
20 5 cc/hr
30 18 cc/hr
40 50 cc/hr

This limited renal resorptive function explains the “physiologic” decrease in bicarbonate (and corresponding acidosis) in newborns (pH 7.26-7.29 at birth, 7.37 at 24h, 7.40 at 1 week)

Estimated blood volume changes with age – at term, the body is 78% water, and adult proportions are not reached until between 9 and 24 months.

Infants have higher plasma chloride and lower bicarbonate (and pH). In the first ten days of life, normal K values may be as high as 6.5 mEq/L. This drops to 3.5-5.5 mEq/L after 2-3 weeks of life. Water exchange is also negative during the first week of life due to limited intake. Infants are at high risk for both over and under hydration

Children

Maintenance Requirements in Children

Weight (kg) Maintenance Requirements in Children (mL/hour)
0-10 4 (mL/kg)
11-20 40 + 2 (mL/kg)
> 20 kg 60 + 1 (mL/kg)

Replacement of Losses

Procedure Insesnsible losses
Non-invasive (inguinal hernia, clubfoot) 0-2 cc/kg/hr
Mildly invasive (uteteral reimplantation) 2-4 cc/kg/hr
Moderately invasive (bowel reanastamosis) 4-8 cc/kg/hr
Significantly invasive (NEC) > 10 cc/kg/hr

Endocrine

Intraoperative Glucose Infants: 4 mg/kg/min = 240 mg/kg/hr maintenance requirements D5 = 50 mg/mL Delivery of D5 @ > 4 mL/kg/hr may lead to hyperglycemia

Hematology

At birth, full term infants have 18-20 g/dL of hemoglobin, 75% of which is HgF (which normalizes by 3-6 months). Hgb will naturally decrease as the infant progresses, reaching a nadir as low as 9-10 g/dL (avg 11.2 g/dL) around 2 months of age [Harriet Lane, 16th ed. CV Mosby, 2002]. In premature infants, however, the nadir may be as low as 6-7 g/dL at 3 or 4 months of age

Cross matched blood should be available for newborn surgery. Assessment of clotting function should be considered because prothrombin as well as factors II, VII, and X are limited in young livers

Blocks

Caudal Block

  • Equipment: 22g B-bevel needle (or angiocath)
  • Drugs: 0.25% bupivacaine or 0.2% ropivacaine +/- morphine 25 ucg/kg or hydromorphone 6 ucg/kg
  • Desired level and volume:
    • Sacral Block: 0.5 ml/kg
    • Midthoracic Block: 1.25 ml/kg

Complicating Issues in Peds

Upper Respiratory Tract Infection

Children recovering from URI are at increased risk for respiratory complications. For short procedures via mask, the increased risk is minimal. If reactive airways accompany the infection, the effects of URI may last 2-7 weeks. In particular, those who already have asthma, bronchopulmonary dysplasia, < 1 yoa, sickle cell, or live in a household of smokers are at high risk, suggesting a “two hit” phenomena [Tait et. al. Anesthesiology 95: 299, 2001]. Bronchial hyperreactivity may last as long as 7 weeks after URI [Collier et. al. Am Rev Resp Dis 117: 47, 1978]. Note that in these patients MASK anesthetics have significantly lower complications than LMA or ETT

If an ETT tube is required, the risk of anesthesia in an infant can be increased as much as 10-fold when compared to an infant with no URI and which does not require ETT. Risk of an LMA are about halfway between those of a facemask and an ETT

Postoperative Croup (< 3 hrs after extubation)

IV decadron 0.25 – 0.5 mg/kg Racemic epinephrine 0.25-0.5 mL of 2.25% solution in 2.5 ml NS

Outpatient Surgery

Inguinal herniorrhaphy, hypospadias repair, and various orthopedic procedures are performed on an outpatient basis in the pediatric population. LMA + caudal block (1 mg/kg 0.125-0.25% bupivacaine) can provide excellent postoperative pain control and lower the anesthetic requirements. A more dilute anesthetic may be used to maintain ambulation

Ex-Premature Infant

Post-operative apnea is always a concern, however it is impossible to fully develop a monitoring protocol [Cote et. al. Anesthesiology 82: 809, 1995]. Apnea is rare after 48 weeks of conceptual age, but the incidence is not zero. The decision of whether or not to admit an ex-premature infant s/p surgery must be individualized. The most conservative approach would be to admit all infants younger than 60 weeks post-conception but this is often impractical. Note that many of these children have chronic lung conditions that last as many as ten years (mostly secondary to reactive airway disease). Hepatic and renal function, as well as developmental delay may also occur.

Cote combined data from eight prospective studies (255 patients) to develop an algorithm based on gestational age, post-conceptual age, apnea at home, size at gestational age, and anemia [Cote CJ et. al. Anesthesiology 82: 809, 1995]. Cotes data showed that the incidence of apnea following inguinal hernia repair did not fall below 5% until gestational age reached 35 weeks and post-conceptual age reached 48 weeks, and that the incidence of apnea following inguinal hernia repair did not fall below 1% until gestational age reached 32 weeks and post-conceptual age reached 56 weeks (or post-gestational 35 weeks with post-conceptual 54 weeks). Any infant that exhibits apnea, has a history of apnea, or is anemic, should not undergo outpatient surgery.

Formulas

Maintenance Requirements in Children

Weight (kg) Maintenance Requirements in Children (mL/hour)
0-10 4 (mL/kg)
11-20 40 + 2 (mL/kg)
> 20 kg 60 + 1 (mL/kg)

Replacement of Losses

Procedure Insesnsible losses
Non-invasive (inguinal hernia, clubfoot) 0-2 cc/kg/hr
Mildly invasive (uteteral reimplantation) 2-4 cc/kg/hr
Moderately invasive (bowel reanastamosis) 4-8 cc/kg/hr
Significantly invasive (NEC) > 10 cc/kg/hr

Intraoperative Glucose

Infants: 4 mg/kg/min = 240 mg/kg/hr maintenance requirements D5 = 50 mg/mL Delivery of D5 @ > 4 mL/kg/hr may lead to hyperglycemia

Medications for Children

Preoperative Medication in Children

PO Nasal IV IM
Midazolam 0.5 – 1.0 mg/kg 0.05 – 0.10 mg/kg
Fentanyl 1 – 3 ucg/kg
Morphine 0.05 – 0.10 mg/kg
Sufentanil 0.25 – 0.5 ucg/kg
Ketamine 2-4 mg/kg 4-6 mg/kg

Resuscitation Medication in Children

  • Epinephrine = 10-100 ucg/kg for arrest (100 ucg/kg in ETT), 1-4 ucg/kg for hypotension
  • Atropine = 0.01 – 0.02 mg/kg (0.3 mg/kg in ETT) – actual dose 0.1 – 1 mg
  • Adenosine = 0.1 mg/kg (max dose 6 mg)
  • Lidocaine = 1-1.5 mg/kg
  • SCh = 2-3 mg/kg
  • Rocuronium 1 mg/kg
  • Calcium chloride = 10-20 mg/kg (dilute to 10 mg/cc or else veins will sclerose, try to give centrally if possible)
  • Bicarbonate = 1 mEq/kg (dilute to 1 mEq/cc or else veins will sclerose)
  • Naloxone = 0.1 mg/kg
  • DEFIBRILLATION = 2 J/kg (can increase up to 4 J/kg)

Preoperative Medication in Children

  • Midazolam 0.05-0.1 mg/kg IV (0.5-1 mg/kg PO, 15 mg max)
  • Methohexital 1-2 mg/kg IV (25-30 mg/kg PR, 500 mg max)
  • Ketamine 1-2 mg/kg IV, 10 mg/kg IM, 5-8 mg/kg PO
  • Sodium Pentothal 1-2 mg/kg IV (separation), 4-6 mg/kg IV (induction)
  • Propofol 0.1-1 mg/kg IV (separation), 2-4 mg/kg IV (induction)
  • Etomidate 0.2-0.3 mg/kg IV

Antibiotic Doses in Children

  • Cefazolin 25 mg/kg q6-8h up to 1-2 grams
  • Cefotaxime 20-30 mg/kg q6h
  • Ampicillin 50-100 mg/kg q6h up to 3 grams
  • Gentamicin 2-2.5 mg/kg q8h (must monitor serum levels, longer interval in renal impairment)
  • Clindamycin 5-10 mg/kg q6-8h up to 900mg
  • Mezlocillinn 50-100 mg/kg q6h up to 2g
  • Vancomycin 10 mg/kg q6h up to 1g

Other Useful Medication in Children

  • Glycopyrrolate 0.01 mg/kg IV, IM, ETT (max 0.4 mg)
  • Morphine 0.05 – 0.1 mg/kg IV (max 0.4 mg/kg)
  • Fentanyl 1-5 ucg/kg IV
  • Ketorolac 0.5 mg/kg IV
  • Tylenol 20 mg/kg PO, 40 mg/kg PR, IV 10-15mg/kg
  • Zofran 0.05-0.15 mg/kg
  • Droperidol 20-25 ucg/kg
  • Dexamethasone 0.1-0.5 mg/kg for pain, N/V prophylaxis
  • Neostigmine 0.07 mg/kg
  • Dexamethasone 0.5-1 mg/kg for tracheal edema
  • Solumedrol 1 mg/kg IV
  • Dexmedatomidine (Precedex) 0.3-0.5mcg/kg slowly at end of case prophylaxis for emergence delerium

Sources

Smith’s Anesthesia for Infants and Children, 8th Edition. Chapters 5, 30, 39 (TABLE 30-5)

PubMed

G E Rasmussen, C M Grande Blood, fluids, and electrolytes in the pediatric trauma patient. Int Anesthesiol Clin: 1994, 32(1);79-101 [PubMed:8144255]

Carcinoid Triad

Another kind of Triad: The Three Body Problem

Carcinoid Tumors and Anesthesia: Notes from TrueLearn

Carcinoid Tumors: Slow growing, benign, small intestine tumors that can metastasize

Hormonal secreting tumors -> cause cutaneous flushing of head neck and thorax, bronchoconstriction, hypotenion, diarrhea, heart disease

Carcinoid Crisis: triggered by physical/chemical such as histamin release, serotonin, bradykinin

Other triggers include: chemo, tumor necrosis, or succinycholine induced fasciculations!

Anesthestic management: avoid histamine release (succ, atracurium, thiopental, morphine, vancomycin); Desflurane good for patients with liver metastasis as low hepatic metabolism (0.02%); Also the use of NE, epi, Dopamine and isoproternol a/w carcinoid crisis

Carcinoid Heart Disease seen in 60% of patients with carcinoid ->right side:  tricuspid and pulmonic valves (plaque like deposits on valves) with TR as most common finding; 50% of carcinoid deaths are from cardiac involvement

So Carcinoid Triad = flushing, diarrhea and cardiac involvement

Management I/O And Peri-Op:

Carcinoid tumors secrete variety of substances (serotonin, catecholamines, histamine)

Somatostatin therapy is standard of care

Be prepared for rapid BP changes
-alpha/beta blockers for HTN
-Vaso for hypotension, or neo

Avoid: Beta agonists -> increased release of from carinoid !

https://www.openanesthesia.org/carcinoid_crisis_treatment/

 

 

Fluorite

Calcium Fluoride

http://www.apsf.org/newsletters/html/2007/fall/03_sevoflurane.htm

Sevoflurane: The Challenges of Safe Formulation

Do you know the water content of your sevo?

From the anesthesia patient safety foundation newsletter:

An incident of Lewis acid mediated sevoflurane degradation occurred in 1996.5,6 Several bottles of sevoflurane had cloudy drug, a pungent odor, marked acidity (pH <1), and high fluoride (863 ppm), all indicating substantial anesthetic degradation and formation of HF, in quantities far exceeding the safe limits of 3 ppm over an 8 hr average. Abbott subsequently determined that increasing the water content in sevoflurane formulations decreased Lewis acid-dependent sevoflurane degradation.7 They changed the sevoflurane formulation to contain at least 300 ppm water, in order to prevent Lewis acid degradation and formation of toxic degradants. The new “water-enhanced” sevoflurane formulation was approved later that year by the U.S. Food and Drug Administration (FDA), and awarded patent protection.

Why is all this important? Generic sevoflurane formulations do not contain Lewis acid inhibitors, nor can they contain water in concentrations higher than 130 ppm. As Dr. Baker concludes, “a potential remains for sevoflurane instability, . . . therefore some vigilance regarding product integrity remains prudent.”

Quick Hit: Myotonic Dystrophy

Myotonic Dystrophy
Quick hit notes from QBanks and Obstetric Anesthesia and Uncommon Disorders

-autosomal dominant CTG-trinucleotide repeat
-impaired muslce relaxation
-Succinycholine –> excessive fasciulations, difficult intubation
-restrictive lung disease -> P/O resp failure
-poor cough/pharyngeal muscle dysynch. -> aspiration/PNA
-imparied response to hypoxia and hypercarbia (senstive to opioids, benzos, barbs, inh)
-comorbidities include: cardiomypathy/dysrhythmias/av block, DM, adreneal insufficiency, thyroid dysfx
-OB pt with MD: increased heart failure risk and myotonic crisis, also increased is placenta accreta, failed labor
-Monitoring: Myotnoia can appear as sustainaed tetanus (even if there is actually sig blockade) -> too early extubations
-MYOTONIC CRISIS: marked contracture of skeletal muscles, 2-3+minutes, ventilation compromised, NOT relieved by nerve block/nmbd/GA
-Prevent Crisis: Warm patient, handle muscles gently, avoid succ and shivering
-Treat Crisis: Procainamide (100mg/min to 1g caution with conduction defects), dantrolene, phenytoin (if localized only, some suggest direct injection of local anesth into muscle)
Plan: avoid succ, easy on resp depressant meds, no superior regional vs. GA

Ketamine for Total Hip Arthroplasty

Bad Times in the K Hole
Bad Times in the K Hole

From: http://www.ncbi.nlm.nih.gov/pubmed/19923527
Anesth Analg. 2009 Dec;109(6):1963-71. doi: 10.1213/ANE.0b013e3181bdc8a0.

The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study.

The gist: Ketamine can reduce post-op pain scores and is opioid sparing when given to patients undergoing General Anesthesia hip replacement (note this is NOT generalizable to spinal anesthesia)

Methods: Pts received IV ketamine before incision (0.5 mg/kg), and a 24-h infusion (2 microg x kg(-1) x min(-1)) or a similar blinded saline bolus and infusion. Postoperative analgesia included IV acetaminophen, ketoprofen, plus morphine/droperidol patient-controlled analgesia for 48 h

Results: Ketamine decreased morphine consumption at 24 h from 19 +/- 12 mg to 14 +/- 13 mg (P = 0.004). At Day 30, ketamine decreased the proportion of patients needing 2 crutches or a walking frame from 56% to 31% (P = 0.0035). From Day 30 to Day 180, ketamine decreased the proportion of patients with persistent pain at rest in the operated hip (P = 0.008).

Other evidence [apparently – I’m looking at you DP who never bothers to comment] shows the one time bolus 0.5mg/kg vs. infusion makes little difference in post-op pain scores… so go for the bolus!

 

 

Magnesium: a versatile drug for anesthesiologists

From: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726845/

MOA: multiple including blockade of nmda and Calcium channels 

Magnesium has multiple advantages including:

  • Reduced opioid reqs post op
  • Reduced Mac with tiva
  • Tiva reduced remi use -> reduced hyperanalgesia post op
  • Intrathecal MG prolongs labor analgesia, especially motor block and iv Mg prolongs muscle blockade when spinal wearing out 
  • Potentiates Nondepolarizing blockade,  can improve incubating conditions while reducing hemodynamic response to intubation 
  • Reduced post op shivering >70%

However caution:

  • Reduced inh Mac questionable 
  • Blunts release of NE / epi watch out in critically ill patients 
  • Cardiovascular depression possible when given as bolus 

Dosing: 

loading dose of 30-50 mcg/kg followed by a maintenance dose of 6-20 mcg/kg/h (continuous infusion) until the end of surgery; alternatively 4mg bolus